The visitors needed some time to get going, trailing 14-8 at the midway mark of the 1st quarter.
Reynolds sparked the comeback, scoring seven points over the next three minutes, while Philip Scrubb and Codi Miller-McIntyre knocked down 3’s to put Zenit in front, 21-19.
Zenit never trailed again, racing out to a 20-point lead in the 2nd quarter behind a 18-0 run.
Down 15 at halftime, Tsmoki-Minsk fell behind by as much as 27 in the second half and never threatened, despite limiting St. Petersburg to five points in the final period.
Both teams struggled from beyond the arc (30% for Zenit, 25% for Minsk), but the Russian club dished out 23 assists and only committed a nine turnovers.
Tsmoki-Minsk – Zenit 68:79 (23-27, 13-24, 13-23, 19-5).
Tsmoki-Minsk: Saddler (15+6 assists), Mihailovic (14+7 rebounds +5 assists), Trastinetski (5), Meshcharakou (4), Liutuc (2), Abrams (17+5 rebounds), Rush(6), Sarikopoulos (12), Kudrautsau (3), Belenkov (0), Paliashchuk (0).